Qingjun Wang, PhD

About

Autophagy, metabolism, omics, and human diseases including cancer.

HSRB 260
Lexington, KY 40536
United States

Induction of autophagy in axonal dystrophy and degeneration.
Wang QJ, Ding Y, Kohtz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z (2006) J Neurosci 26(31):8057-8068. PMID: 16885219.
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration.
Komatsu M*, Wang QJ*, Holstein GR, Friedrich Jr VL, Iwata JI, Kominami E, Chait BT, Tanaka K, Yue Z (2007) Proc Natl Acad Sci U S A 104(36):14489-14494. PMID: 17726112 (*Equal contributors; direct submission).
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol 3-kinase complex.
Zhong Y*, Wang QJ*, Li X, Chait BT, Heintz N, Yue Z (2009) Nat Cell Biol 11:468-476. PMID: 19270693 (*Equal contributors).
Nrbf2 suppresses autophagy by modulating Atg14L-containing Beclin 1-Vps34 protein complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.
Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ (2014) J Biol Chem 289(38):26021-26037. PMID: 25086043.
Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.
Ouseph MM, Huang Y, Banerjee M, Joshi S, MacDonald L, Zhong Y, Liu H, Li X, Xiang B, Zhang G, Komatsu M, Yue Z, Li Z, Storrie B, Whiteheart SW, Wang QJ (2015) Blood 126(10):1224-1233. PMID: 26209658.